This PARP Research Products market report explores are a superfamily of 18 proteins, of which PARP-1 is the best characterized. They are enzymes that are activated by DNA breaks to facilitate DNA repair.

Currently, there is a great deal of research being done on this family of polymerases, because its activity is linked to serious disease conditions, including cancer, ischemia, diabetes, arthritis, inflammatory bowel disease, and septic shock. Of greatest therapeutical interest are PARP-1 inhibitors, as they exert a duel effect of inhibiting cell death and reducing inflammation. Indeed, these inhibitors have been shown to be effective as radiation-sensitizing agents and appear promising in the treatment of conditions involving oxidative stress. Additionally, quantification of poly(ADP-ribose) polymerase activity and identification of abnormal patterns of its degradation by proteases might have utility in the diagnosis various conditions.

At this time, there are a limited number of research products available to this research community. Commercially available research tools include enzymes, antibodies, inhibitors, and assay kits designed for the measurement of poly(ADP-ribose) polymerase activity. Because of the size and growth potential of this research products market, providing products to this market niche represents a significant financial opportunity. This report is an in-depth exploration of this research products market, including market conditions, dominant competitors, clinical applications, and product opportunities available to companies interested in this lucrative, early-stage market.

I. ABSTRACT

II. BACKGROUND

A. Introduction
B. PARP Superfamily

1. Characterized Isoforms
2. Comparison of domain structures of PARP isoforms

C. Active / Inactive States of PARP-1
D. Severity of Damage Regulates Repair Processes
E. Regulation of DNA Repair by NAD
F. PARP-1 Inhibition
G. PARP-1 Degradation by Proteases

III. APPLICATIONS

A. Basic Research

1. Current Applications
2. Future Applications

B. Diagnostic Applications

1. Current Applications
2. Future Applications

C. Future Applications

1. Current Applications
2. Future Applications

IV. PARP MARKET COMPETITION

A.Comprehensive List of PARP Research Product Companies
B. Dominant Competitors

V. MARKET SIZZE DETERMINATION

A. Experimental Approach
B. Annual Worldwide Market Size, Broken Down by Individual Company

VI. MARKET ASSESSMENT

A. Federal Funding for PARP Research
B. Pharmaceutical Development of PARP-1 Inhibitors

1. Inotek Pharmaceuticals
2. Guilford Pharmaceuticals
3. Niadyne Pharmaceuticals
4. Agouron Pharmaceuticals
5. Octamer, Incorporated

C. Private Funding
D. User Consumption of PARP Research Products

1. Geographic Distribution of PARP Research Labs
2. Patents
3. Publications
4. Growth Rate Determination
5. 5 Year Projections
6. Factors Contributing to Market Growth

VII. COMPETITIVE LANDSCAPE

A. Market Opportunities
B. Market Risks

VIII. RESEARCH PRODUCTS OVERVIEW

A. Product Line Divisions
B. Dominant Product Areas
C. Expansion into Related Product Areas
D. Novel Product Opportunities and Suggestions
E. Communication Strategies for Accessing the Marketplace
F. Potential Strategic Alliances

APPENDIX: Supplemental Documents

REFERENCES

MarketsandMarkets.com publishes about 120 report a year across 10 main industries. The reports are exhaustive reports with about 50 micro markets and product segments, about 80 to 100 market data summary tables, 50 short company profiles, market breakdown upto 5 levels, strategic and competitive landscape, patent overview of more than 300 patents.

MarketsandMarkets.com publishes about 120 report a year across 10 main industries. The reports are exhaustive reports with about 50 micro markets and product segments, about 80 to 100 market data summary tables, 50 short company profiles, market breakdown upto 5 levels, strategic and competitive landscape, patent overview of more than 300 patents.